The Application of Arsenic Trioxide in Ameliorating ABT-737 Target Therapy on Uterine Cervical Cancer Cells through Unique Pathways in Cell Death
Identifieur interne : 000368 ( Main/Exploration ); précédent : 000367; suivant : 000369The Application of Arsenic Trioxide in Ameliorating ABT-737 Target Therapy on Uterine Cervical Cancer Cells through Unique Pathways in Cell Death
Auteurs : I-Lun Hsin ; Ying-Hsiang Chou [Taïwan] ; Wei-Li Hung ; Jiunn-Liang Ko ; Po-Hui Wang [Taïwan]Source :
- Cancers [ 2072-6694 ] ; 2019.
Abstract
ABT-737, a B cell lymphoma-2 (Bcl-2) family inhibitor, activates apoptosis in cancer cells. Arsenic trioxide is an apoptosis activator that impairs cancer cell survival. The aim of this study was to evaluate the effect of a combination treatment with ABT-737 and arsenic trioxide on uterine cervical cancer cells. MTT (3-(4,5-dimethylthiazol-2-yl)-25-diphenyltetrazolium bromide) assay revealed that ABT-737 and arsenic trioxide induced a synergistic effect on uterine cervical cancer cells. Arsenic trioxide enhanced ABT-737-induced apoptosis and caspase-7 activation and the ABT-737-mediated reduction of anti-apoptotic protein Mcl-1 in Caski cells. Western blot assay revealed that arsenic trioxide promoted the ABT-737-mediated reduction of CDK6 and thymidylate synthetase in Caski cells. Arsenic trioxide promoted ABT-737-inhibited mitochondrial membrane potential and ABT-737-inhibited ANT expression in Caski cells. However, ABT-737-elicited reactive oxygen species were not enhanced by arsenic trioxide. The combined treatment induced an anti-apoptosis autophagy in SiHa cells. This study is the first to demonstrate that a combination treatment with ABT-737 and arsenic trioxide induces a synergistic effect on uterine cervical cancer cells through apoptosis. Our findings provide new insights into uterine cervical cancer treatment.
Url:
DOI: 10.3390/cancers12010108
PubMed: 31906234
PubMed Central: 7016694
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000463
- to stream Pmc, to step Curation: 000463
- to stream Pmc, to step Checkpoint: 000331
- to stream Ncbi, to step Merge: 000E00
- to stream Ncbi, to step Curation: 000E00
- to stream Ncbi, to step Checkpoint: 000E00
- to stream Main, to step Merge: 000368
- to stream Main, to step Curation: 000368
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The Application of Arsenic Trioxide in Ameliorating ABT-737 Target Therapy on Uterine Cervical Cancer Cells through Unique Pathways in Cell Death</title><author><name sortKey="Hsin, I Lun" sort="Hsin, I Lun" uniqKey="Hsin I" first="I-Lun" last="Hsin">I-Lun Hsin</name><affiliation><nlm:aff id="af1-cancers-12-00108">Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan<email>hideka.chou@gmail.com</email> (Y.-H.C.);<email>ayuatsushi@hotmail.com</email> (W.-L.H.);<email>jlko@csmu.edu.tw</email> (J.-L.K.)</nlm:aff></affiliation></author><author><name sortKey="Chou, Ying Hsiang" sort="Chou, Ying Hsiang" uniqKey="Chou Y" first="Ying-Hsiang" last="Chou">Ying-Hsiang Chou</name><affiliation><nlm:aff id="af1-cancers-12-00108">Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan<email>hideka.chou@gmail.com</email> (Y.-H.C.);<email>ayuatsushi@hotmail.com</email> (W.-L.H.);<email>jlko@csmu.edu.tw</email> (J.-L.K.)</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-cancers-12-00108">Department of Medical Imaging and Radiological Sciences, Chung Shan Medical University, Taichung 40201, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Medical Imaging and Radiological Sciences, Chung Shan Medical University, Taichung 40201</wicri:regionArea><wicri:noRegion>Taichung 40201</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af3-cancers-12-00108">Department of Radiation Oncology, Chung Shan Medical University Hospital, Taichung 40201, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Radiation Oncology, Chung Shan Medical University Hospital, Taichung 40201</wicri:regionArea><wicri:noRegion>Taichung 40201</wicri:noRegion></affiliation></author><author><name sortKey="Hung, Wei Li" sort="Hung, Wei Li" uniqKey="Hung W" first="Wei-Li" last="Hung">Wei-Li Hung</name><affiliation><nlm:aff id="af1-cancers-12-00108">Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan<email>hideka.chou@gmail.com</email> (Y.-H.C.);<email>ayuatsushi@hotmail.com</email> (W.-L.H.);<email>jlko@csmu.edu.tw</email> (J.-L.K.)</nlm:aff></affiliation></author><author><name sortKey="Ko, Jiunn Liang" sort="Ko, Jiunn Liang" uniqKey="Ko J" first="Jiunn-Liang" last="Ko">Jiunn-Liang Ko</name><affiliation><nlm:aff id="af1-cancers-12-00108">Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan<email>hideka.chou@gmail.com</email> (Y.-H.C.);<email>ayuatsushi@hotmail.com</email> (W.-L.H.);<email>jlko@csmu.edu.tw</email> (J.-L.K.)</nlm:aff></affiliation></author><author><name sortKey="Wang, Po Hui" sort="Wang, Po Hui" uniqKey="Wang P" first="Po-Hui" last="Wang">Po-Hui Wang</name><affiliation><nlm:aff id="af1-cancers-12-00108">Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan<email>hideka.chou@gmail.com</email> (Y.-H.C.);<email>ayuatsushi@hotmail.com</email> (W.-L.H.);<email>jlko@csmu.edu.tw</email> (J.-L.K.)</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af4-cancers-12-00108">Department of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taichung 40201, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taichung 40201</wicri:regionArea><wicri:noRegion>Taichung 40201</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af5-cancers-12-00108">School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>School of Medicine, Chung Shan Medical University, Taichung 40201</wicri:regionArea><wicri:noRegion>Taichung 40201</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af6-cancers-12-00108">Department of Medical Research, Chung Shan Medical University Hospital, Taichung 40201, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Medical Research, Chung Shan Medical University Hospital, Taichung 40201</wicri:regionArea><wicri:noRegion>Taichung 40201</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31906234</idno><idno type="pmc">7016694</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016694</idno><idno type="RBID">PMC:7016694</idno><idno type="doi">10.3390/cancers12010108</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000463</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000463</idno><idno type="wicri:Area/Pmc/Curation">000463</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000463</idno><idno type="wicri:Area/Pmc/Checkpoint">000331</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000331</idno><idno type="wicri:Area/Ncbi/Merge">000E00</idno><idno type="wicri:Area/Ncbi/Curation">000E00</idno><idno type="wicri:Area/Ncbi/Checkpoint">000E00</idno><idno type="wicri:Area/Main/Merge">000368</idno><idno type="wicri:Area/Main/Curation">000368</idno><idno type="wicri:Area/Main/Exploration">000368</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The Application of Arsenic Trioxide in Ameliorating ABT-737 Target Therapy on Uterine Cervical Cancer Cells through Unique Pathways in Cell Death</title><author><name sortKey="Hsin, I Lun" sort="Hsin, I Lun" uniqKey="Hsin I" first="I-Lun" last="Hsin">I-Lun Hsin</name><affiliation><nlm:aff id="af1-cancers-12-00108">Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan<email>hideka.chou@gmail.com</email> (Y.-H.C.);<email>ayuatsushi@hotmail.com</email> (W.-L.H.);<email>jlko@csmu.edu.tw</email> (J.-L.K.)</nlm:aff></affiliation></author><author><name sortKey="Chou, Ying Hsiang" sort="Chou, Ying Hsiang" uniqKey="Chou Y" first="Ying-Hsiang" last="Chou">Ying-Hsiang Chou</name><affiliation><nlm:aff id="af1-cancers-12-00108">Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan<email>hideka.chou@gmail.com</email> (Y.-H.C.);<email>ayuatsushi@hotmail.com</email> (W.-L.H.);<email>jlko@csmu.edu.tw</email> (J.-L.K.)</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-cancers-12-00108">Department of Medical Imaging and Radiological Sciences, Chung Shan Medical University, Taichung 40201, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Medical Imaging and Radiological Sciences, Chung Shan Medical University, Taichung 40201</wicri:regionArea><wicri:noRegion>Taichung 40201</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af3-cancers-12-00108">Department of Radiation Oncology, Chung Shan Medical University Hospital, Taichung 40201, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Radiation Oncology, Chung Shan Medical University Hospital, Taichung 40201</wicri:regionArea><wicri:noRegion>Taichung 40201</wicri:noRegion></affiliation></author><author><name sortKey="Hung, Wei Li" sort="Hung, Wei Li" uniqKey="Hung W" first="Wei-Li" last="Hung">Wei-Li Hung</name><affiliation><nlm:aff id="af1-cancers-12-00108">Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan<email>hideka.chou@gmail.com</email> (Y.-H.C.);<email>ayuatsushi@hotmail.com</email> (W.-L.H.);<email>jlko@csmu.edu.tw</email> (J.-L.K.)</nlm:aff></affiliation></author><author><name sortKey="Ko, Jiunn Liang" sort="Ko, Jiunn Liang" uniqKey="Ko J" first="Jiunn-Liang" last="Ko">Jiunn-Liang Ko</name><affiliation><nlm:aff id="af1-cancers-12-00108">Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan<email>hideka.chou@gmail.com</email> (Y.-H.C.);<email>ayuatsushi@hotmail.com</email> (W.-L.H.);<email>jlko@csmu.edu.tw</email> (J.-L.K.)</nlm:aff></affiliation></author><author><name sortKey="Wang, Po Hui" sort="Wang, Po Hui" uniqKey="Wang P" first="Po-Hui" last="Wang">Po-Hui Wang</name><affiliation><nlm:aff id="af1-cancers-12-00108">Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan<email>hideka.chou@gmail.com</email> (Y.-H.C.);<email>ayuatsushi@hotmail.com</email> (W.-L.H.);<email>jlko@csmu.edu.tw</email> (J.-L.K.)</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af4-cancers-12-00108">Department of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taichung 40201, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taichung 40201</wicri:regionArea><wicri:noRegion>Taichung 40201</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af5-cancers-12-00108">School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>School of Medicine, Chung Shan Medical University, Taichung 40201</wicri:regionArea><wicri:noRegion>Taichung 40201</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af6-cancers-12-00108">Department of Medical Research, Chung Shan Medical University Hospital, Taichung 40201, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Medical Research, Chung Shan Medical University Hospital, Taichung 40201</wicri:regionArea><wicri:noRegion>Taichung 40201</wicri:noRegion></affiliation></author></analytic><series><title level="j">Cancers</title><idno type="eISSN">2072-6694</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>ABT-737, a B cell lymphoma-2 (Bcl-2) family inhibitor, activates apoptosis in cancer cells. Arsenic trioxide is an apoptosis activator that impairs cancer cell survival. The aim of this study was to evaluate the effect of a combination treatment with ABT-737 and arsenic trioxide on uterine cervical cancer cells. MTT (3-(4,5-dimethylthiazol-2-yl)-25-diphenyltetrazolium bromide) assay revealed that ABT-737 and arsenic trioxide induced a synergistic effect on uterine cervical cancer cells. Arsenic trioxide enhanced ABT-737-induced apoptosis and caspase-7 activation and the ABT-737-mediated reduction of anti-apoptotic protein Mcl-1 in Caski cells. Western blot assay revealed that arsenic trioxide promoted the ABT-737-mediated reduction of CDK6 and thymidylate synthetase in Caski cells. Arsenic trioxide promoted ABT-737-inhibited mitochondrial membrane potential and ABT-737-inhibited ANT expression in Caski cells. However, ABT-737-elicited reactive oxygen species were not enhanced by arsenic trioxide. The combined treatment induced an anti-apoptosis autophagy in SiHa cells. This study is the first to demonstrate that a combination treatment with ABT-737 and arsenic trioxide induces a synergistic effect on uterine cervical cancer cells through apoptosis. Our findings provide new insights into uterine cervical cancer treatment.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Willis, S N" uniqKey="Willis S">S.N. Willis</name></author><author><name sortKey="Adams, J M" uniqKey="Adams J">J.M. Adams</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oltersdorf, T" uniqKey="Oltersdorf T">T. Oltersdorf</name></author><author><name sortKey="Elmore, S W" uniqKey="Elmore S">S.W. Elmore</name></author><author><name sortKey="Shoemaker, A R" uniqKey="Shoemaker A">A.R. Shoemaker</name></author><author><name sortKey="Armstrong, R C" uniqKey="Armstrong R">R.C. Armstrong</name></author><author><name sortKey="Augeri, D J" uniqKey="Augeri D">D.J. Augeri</name></author><author><name sortKey="Belli, B A" uniqKey="Belli B">B.A. Belli</name></author><author><name sortKey="Bruncko, M" uniqKey="Bruncko M">M. Bruncko</name></author><author><name sortKey="Deckwerth, T L" uniqKey="Deckwerth T">T.L. Deckwerth</name></author><author><name sortKey="Dinges, J" uniqKey="Dinges J">J. Dinges</name></author><author><name sortKey="Hajduk, P J" uniqKey="Hajduk P">P.J. Hajduk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yecies, D" uniqKey="Yecies D">D. Yecies</name></author><author><name sortKey="Carlson, N E" uniqKey="Carlson N">N.E. Carlson</name></author><author><name sortKey="Deng, J" uniqKey="Deng J">J. Deng</name></author><author><name sortKey="Letai, A" uniqKey="Letai A">A. Letai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, S" uniqKey="Chen S">S. Chen</name></author><author><name sortKey="Dai, Y" uniqKey="Dai Y">Y. Dai</name></author><author><name sortKey="Harada, H" uniqKey="Harada H">H. Harada</name></author><author><name sortKey="Dent, P" uniqKey="Dent P">P. Dent</name></author><author><name sortKey="Grant, S" uniqKey="Grant S">S. Grant</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Konopleva, M" uniqKey="Konopleva M">M. Konopleva</name></author><author><name sortKey="Contractor, R" uniqKey="Contractor R">R. Contractor</name></author><author><name sortKey="Tsao, T" uniqKey="Tsao T">T. Tsao</name></author><author><name sortKey="Samudio, I" uniqKey="Samudio I">I. Samudio</name></author><author><name sortKey="Ruvolo, P P" uniqKey="Ruvolo P">P.P. Ruvolo</name></author><author><name sortKey="Kitada, S" uniqKey="Kitada S">S. Kitada</name></author><author><name sortKey="Deng, X" uniqKey="Deng X">X. Deng</name></author><author><name sortKey="Zhai, D" uniqKey="Zhai D">D. Zhai</name></author><author><name sortKey="Shi, Y X" uniqKey="Shi Y">Y.X. Shi</name></author><author><name sortKey="Sneed, T" uniqKey="Sneed T">T. Sneed</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mason, K D" uniqKey="Mason K">K.D. Mason</name></author><author><name sortKey="Vandenberg, C J" uniqKey="Vandenberg C">C.J. Vandenberg</name></author><author><name sortKey="Scott, C L" uniqKey="Scott C">C.L. Scott</name></author><author><name sortKey="Wei, A H" uniqKey="Wei A">A.H. Wei</name></author><author><name sortKey="Cory, S" uniqKey="Cory S">S. Cory</name></author><author><name sortKey="Huang, D C" uniqKey="Huang D">D.C. Huang</name></author><author><name sortKey="Roberts, A W" uniqKey="Roberts A">A.W. Roberts</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kutuk, O" uniqKey="Kutuk O">O. Kutuk</name></author><author><name sortKey="Letai, A" uniqKey="Letai A">A. Letai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yu, X" uniqKey="Yu X">X. Yu</name></author><author><name sortKey="Dobrikov, M" uniqKey="Dobrikov M">M. Dobrikov</name></author><author><name sortKey="Keir, S T" uniqKey="Keir S">S.T. Keir</name></author><author><name sortKey="Gromeier, M" uniqKey="Gromeier M">M. Gromeier</name></author><author><name sortKey="Pastan, I H" uniqKey="Pastan I">I.H. Pastan</name></author><author><name sortKey="Reisfeld, R" uniqKey="Reisfeld R">R. Reisfeld</name></author><author><name sortKey="Bigner, D D" uniqKey="Bigner D">D.D. Bigner</name></author><author><name sortKey="Chandramohan, V" uniqKey="Chandramohan V">V. Chandramohan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shen, J" uniqKey="Shen J">J. Shen</name></author><author><name sortKey="Xu, L" uniqKey="Xu L">L. Xu</name></author><author><name sortKey="Zhao, Q" uniqKey="Zhao Q">Q. Zhao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hwang, E" uniqKey="Hwang E">E. Hwang</name></author><author><name sortKey="Hwang, S H" uniqKey="Hwang S">S.H. Hwang</name></author><author><name sortKey="Kim, J" uniqKey="Kim J">J. Kim</name></author><author><name sortKey="Park, J H" uniqKey="Park J">J.H. Park</name></author><author><name sortKey="Oh, S" uniqKey="Oh S">S. Oh</name></author><author><name sortKey="Kim, Y A" uniqKey="Kim Y">Y.A. Kim</name></author><author><name sortKey="Hwang, K T" uniqKey="Hwang K">K.T. Hwang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Antman, K H" uniqKey="Antman K">K.H. Antman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kumar, S" uniqKey="Kumar S">S. Kumar</name></author><author><name sortKey="Yedjou, C G" uniqKey="Yedjou C">C.G. Yedjou</name></author><author><name sortKey="Tchounwou, P B" uniqKey="Tchounwou P">P.B. Tchounwou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yu, J" uniqKey="Yu J">J. Yu</name></author><author><name sortKey="Qian, H" uniqKey="Qian H">H. Qian</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y. Li</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y. Wang</name></author><author><name sortKey="Zhang, X" uniqKey="Zhang X">X. Zhang</name></author><author><name sortKey="Liang, X" uniqKey="Liang X">X. Liang</name></author><author><name sortKey="Fu, M" uniqKey="Fu M">M. Fu</name></author><author><name sortKey="Lin, C" uniqKey="Lin C">C. Lin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, L" uniqKey="Zhang L">L. Zhang</name></author><author><name sortKey="Liu, L" uniqKey="Liu L">L. Liu</name></author><author><name sortKey="Zhan, S" uniqKey="Zhan S">S. Zhan</name></author><author><name sortKey="Chen, L" uniqKey="Chen L">L. Chen</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y. Wang</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y. Zhang</name></author><author><name sortKey="Du, J" uniqKey="Du J">J. Du</name></author><author><name sortKey="Wu, Y" uniqKey="Wu Y">Y. Wu</name></author><author><name sortKey="Gu, L" uniqKey="Gu L">L. Gu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Qiu, Y" uniqKey="Qiu Y">Y. Qiu</name></author><author><name sortKey="Dai, Y" uniqKey="Dai Y">Y. Dai</name></author><author><name sortKey="Zhang, C" uniqKey="Zhang C">C. Zhang</name></author><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y. Yang</name></author><author><name sortKey="Jin, M" uniqKey="Jin M">M. Jin</name></author><author><name sortKey="Shan, W" uniqKey="Shan W">W. Shan</name></author><author><name sortKey="Shen, J" uniqKey="Shen J">J. Shen</name></author><author><name sortKey="Lu, M" uniqKey="Lu M">M. Lu</name></author><author><name sortKey="Tang, Z" uniqKey="Tang Z">Z. Tang</name></author><author><name sortKey="Ju, L" uniqKey="Ju L">L. Ju</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Antignani, A" uniqKey="Antignani A">A. Antignani</name></author><author><name sortKey="Youle, R J" uniqKey="Youle R">R.J. Youle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Annis, M G" uniqKey="Annis M">M.G. Annis</name></author><author><name sortKey="Soucie, E L" uniqKey="Soucie E">E.L. Soucie</name></author><author><name sortKey="Dlugosz, P J" uniqKey="Dlugosz P">P.J. Dlugosz</name></author><author><name sortKey="Cruz Aguado, J A" uniqKey="Cruz Aguado J">J.A. Cruz-Aguado</name></author><author><name sortKey="Penn, L Z" uniqKey="Penn L">L.Z. Penn</name></author><author><name sortKey="Leber, B" uniqKey="Leber B">B. Leber</name></author><author><name sortKey="Andrews, D W" uniqKey="Andrews D">D.W. Andrews</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dlugosz, P J" uniqKey="Dlugosz P">P.J. Dlugosz</name></author><author><name sortKey="Billen, L P" uniqKey="Billen L">L.P. Billen</name></author><author><name sortKey="Annis, M G" uniqKey="Annis M">M.G. Annis</name></author><author><name sortKey="Zhu, W" uniqKey="Zhu W">W. Zhu</name></author><author><name sortKey="Zhang, Z" uniqKey="Zhang Z">Z. Zhang</name></author><author><name sortKey="Lin, J" uniqKey="Lin J">J. Lin</name></author><author><name sortKey="Leber, B" uniqKey="Leber B">B. Leber</name></author><author><name sortKey="Andrews, D W" uniqKey="Andrews D">D.W. Andrews</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shen, H P" uniqKey="Shen H">H.P. Shen</name></author><author><name sortKey="Wu, W J" uniqKey="Wu W">W.J. Wu</name></author><author><name sortKey="Ko, J L" uniqKey="Ko J">J.L. Ko</name></author><author><name sortKey="Wu, T F" uniqKey="Wu T">T.F. Wu</name></author><author><name sortKey="Yang, S F" uniqKey="Yang S">S.F. Yang</name></author><author><name sortKey="Wu, C H" uniqKey="Wu C">C.H. Wu</name></author><author><name sortKey="Yeh, C M" uniqKey="Yeh C">C.M. Yeh</name></author><author><name sortKey="Wang, P H" uniqKey="Wang P">P.H. Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hsin, I L" uniqKey="Hsin I">I.L. Hsin</name></author><author><name sortKey="Ou, C C" uniqKey="Ou C">C.C. Ou</name></author><author><name sortKey="Wu, M F" uniqKey="Wu M">M.F. Wu</name></author><author><name sortKey="Jan, M S" uniqKey="Jan M">M.S. Jan</name></author><author><name sortKey="Hsiao, Y M" uniqKey="Hsiao Y">Y.M. Hsiao</name></author><author><name sortKey="Lin, C H" uniqKey="Lin C">C.H. Lin</name></author><author><name sortKey="Ko, J L" uniqKey="Ko J">J.L. Ko</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hsin, I L" uniqKey="Hsin I">I.L. Hsin</name></author><author><name sortKey="Ou, C C" uniqKey="Ou C">C.C. Ou</name></author><author><name sortKey="Wu, T C" uniqKey="Wu T">T.C. Wu</name></author><author><name sortKey="Jan, M S" uniqKey="Jan M">M.S. Jan</name></author><author><name sortKey="Wu, M F" uniqKey="Wu M">M.F. Wu</name></author><author><name sortKey="Chiu, L Y" uniqKey="Chiu L">L.Y. Chiu</name></author><author><name sortKey="Lue, K H" uniqKey="Lue K">K.H. Lue</name></author><author><name sortKey="Ko, J L" uniqKey="Ko J">J.L. Ko</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hsin, I L" uniqKey="Hsin I">I.L. Hsin</name></author><author><name sortKey="Wang, S C" uniqKey="Wang S">S.C. Wang</name></author><author><name sortKey="Li, J R" uniqKey="Li J">J.R. Li</name></author><author><name sortKey="Ciou, T C" uniqKey="Ciou T">T.C. Ciou</name></author><author><name sortKey="Wu, C H" uniqKey="Wu C">C.H. Wu</name></author><author><name sortKey="Wu, H M" uniqKey="Wu H">H.M. Wu</name></author><author><name sortKey="Ko, J L" uniqKey="Ko J">J.L. Ko</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hsin, I L" uniqKey="Hsin I">I.L. Hsin</name></author><author><name sortKey="Hsu, J C" uniqKey="Hsu J">J.C. Hsu</name></author><author><name sortKey="Wu, W J" uniqKey="Wu W">W.J. Wu</name></author><author><name sortKey="Lu, H J" uniqKey="Lu H">H.J. Lu</name></author><author><name sortKey="Wu, M F" uniqKey="Wu M">M.F. Wu</name></author><author><name sortKey="Ko, J L" uniqKey="Ko J">J.L. Ko</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="St John, J C" uniqKey="St John J">J.C. St John</name></author><author><name sortKey="Amaral, A" uniqKey="Amaral A">A. Amaral</name></author><author><name sortKey="Bowles, E" uniqKey="Bowles E">E. Bowles</name></author><author><name sortKey="Oliveira, J F" uniqKey="Oliveira J">J.F. Oliveira</name></author><author><name sortKey="Lloyd, R" uniqKey="Lloyd R">R. Lloyd</name></author><author><name sortKey="Freitas, M" uniqKey="Freitas M">M. Freitas</name></author><author><name sortKey="Gray, H L" uniqKey="Gray H">H.L. Gray</name></author><author><name sortKey="Navara, C S" uniqKey="Navara C">C.S. Navara</name></author><author><name sortKey="Oliveira, G" uniqKey="Oliveira G">G. Oliveira</name></author><author><name sortKey="Schatten, G P" uniqKey="Schatten G">G.P. Schatten</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shah, B P" uniqKey="Shah B">B.P. Shah</name></author><author><name sortKey="Pasquale, N" uniqKey="Pasquale N">N. Pasquale</name></author><author><name sortKey="De, G" uniqKey="De G">G. De</name></author><author><name sortKey="Tan, T" uniqKey="Tan T">T. Tan</name></author><author><name sortKey="Ma, J" uniqKey="Ma J">J. Ma</name></author><author><name sortKey="Lee, K B" uniqKey="Lee K">K.B. Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Doherty, J" uniqKey="Doherty J">J. Doherty</name></author><author><name sortKey="Baehrecke, E H" uniqKey="Baehrecke E">E.H. Baehrecke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Filippova, M" uniqKey="Filippova M">M. Filippova</name></author><author><name sortKey="Filippov, V" uniqKey="Filippov V">V. Filippov</name></author><author><name sortKey="Williams, V M" uniqKey="Williams V">V.M. Williams</name></author><author><name sortKey="Zhang, K" uniqKey="Zhang K">K. Zhang</name></author><author><name sortKey="Kokoza, A" uniqKey="Kokoza A">A. Kokoza</name></author><author><name sortKey="Bashkirova, S" uniqKey="Bashkirova S">S. Bashkirova</name></author><author><name sortKey="Duerksen Hughes, P" uniqKey="Duerksen Hughes P">P. Duerksen-Hughes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Filippova, M" uniqKey="Filippova M">M. Filippova</name></author><author><name sortKey="Brown Bryan, T A" uniqKey="Brown Bryan T">T.A. Brown-Bryan</name></author><author><name sortKey="Casiano, C A" uniqKey="Casiano C">C.A. Casiano</name></author><author><name sortKey="Duerksen Hughes, P J" uniqKey="Duerksen Hughes P">P.J. Duerksen-Hughes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, S S" uniqKey="Liu S">S.S. Liu</name></author><author><name sortKey="Chan, K Y" uniqKey="Chan K">K.Y. Chan</name></author><author><name sortKey="Leung, R C" uniqKey="Leung R">R.C. Leung</name></author><author><name sortKey="Law, H K" uniqKey="Law H">H.K. Law</name></author><author><name sortKey="Leung, T W" uniqKey="Leung T">T.W. Leung</name></author><author><name sortKey="Ngan, H Y" uniqKey="Ngan H">H.Y. Ngan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kroemer, G" uniqKey="Kroemer G">G. Kroemer</name></author><author><name sortKey="Galluzzi, L" uniqKey="Galluzzi L">L. Galluzzi</name></author><author><name sortKey="Brenner, C" uniqKey="Brenner C">C. Brenner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gottlob, K" uniqKey="Gottlob K">K. Gottlob</name></author><author><name sortKey="Majewski, N" uniqKey="Majewski N">N. Majewski</name></author><author><name sortKey="Kennedy, S" uniqKey="Kennedy S">S. Kennedy</name></author><author><name sortKey="Kandel, E" uniqKey="Kandel E">E. Kandel</name></author><author><name sortKey="Robey, R B" uniqKey="Robey R">R.B. Robey</name></author><author><name sortKey="Hay, N" uniqKey="Hay N">N. Hay</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Halestrap, A P" uniqKey="Halestrap A">A.P. Halestrap</name></author><author><name sortKey="Richardson, A P" uniqKey="Richardson A">A.P. Richardson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chevrollier, A" uniqKey="Chevrollier A">A. Chevrollier</name></author><author><name sortKey="Loiseau, D" uniqKey="Loiseau D">D. Loiseau</name></author><author><name sortKey="Reynier, P" uniqKey="Reynier P">P. Reynier</name></author><author><name sortKey="Stepien, G" uniqKey="Stepien G">G. Stepien</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jang, J Y" uniqKey="Jang J">J.Y. Jang</name></author><author><name sortKey="Kim, Y G" uniqKey="Kim Y">Y.G. Kim</name></author><author><name sortKey="Nam, S J" uniqKey="Nam S">S.J. Nam</name></author><author><name sortKey="Keam, B" uniqKey="Keam B">B. Keam</name></author><author><name sortKey="Kim, T M" uniqKey="Kim T">T.M. Kim</name></author><author><name sortKey="Jeon, Y K" uniqKey="Jeon Y">Y.K. Jeon</name></author><author><name sortKey="Kim, C W" uniqKey="Kim C">C.W. Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shoshan Barmatz, V" uniqKey="Shoshan Barmatz V">V. Shoshan-Barmatz</name></author><author><name sortKey="De Pinto, V" uniqKey="De Pinto V">V. De Pinto</name></author><author><name sortKey="Zweckstetter, M" uniqKey="Zweckstetter M">M. Zweckstetter</name></author><author><name sortKey="Raviv, Z" uniqKey="Raviv Z">Z. Raviv</name></author><author><name sortKey="Keinan, N" uniqKey="Keinan N">N. Keinan</name></author><author><name sortKey="Arbel, N" uniqKey="Arbel N">N. Arbel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vikstrom, I B" uniqKey="Vikstrom I">I.B. Vikstrom</name></author><author><name sortKey="Slomp, A" uniqKey="Slomp A">A. Slomp</name></author><author><name sortKey="Carrington, E M" uniqKey="Carrington E">E.M. Carrington</name></author><author><name sortKey="Moesbergen, L M" uniqKey="Moesbergen L">L.M. Moesbergen</name></author><author><name sortKey="Chang, C" uniqKey="Chang C">C. Chang</name></author><author><name sortKey="Kelly, G L" uniqKey="Kelly G">G.L. Kelly</name></author><author><name sortKey="Glaser, S P" uniqKey="Glaser S">S.P. Glaser</name></author><author><name sortKey="Jansen, J H" uniqKey="Jansen J">J.H. Jansen</name></author><author><name sortKey="Leusen, J H" uniqKey="Leusen J">J.H. Leusen</name></author><author><name sortKey="Strasser, A" uniqKey="Strasser A">A. Strasser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Belmar, J" uniqKey="Belmar J">J. Belmar</name></author><author><name sortKey="Fesik, S W" uniqKey="Fesik S">S.W. Fesik</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wertz, I E" uniqKey="Wertz I">I.E. Wertz</name></author><author><name sortKey="Kusam, S" uniqKey="Kusam S">S. Kusam</name></author><author><name sortKey="Lam, C" uniqKey="Lam C">C. Lam</name></author><author><name sortKey="Okamoto, T" uniqKey="Okamoto T">T. Okamoto</name></author><author><name sortKey="Sandoval, W" uniqKey="Sandoval W">W. Sandoval</name></author><author><name sortKey="Anderson, D J" uniqKey="Anderson D">D.J. Anderson</name></author><author><name sortKey="Helgason, E" uniqKey="Helgason E">E. Helgason</name></author><author><name sortKey="Ernst, J A" uniqKey="Ernst J">J.A. Ernst</name></author><author><name sortKey="Eby, M" uniqKey="Eby M">M. Eby</name></author><author><name sortKey="Liu, J" uniqKey="Liu J">J. Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wei, S H" uniqKey="Wei S">S.H. Wei</name></author><author><name sortKey="Dong, K" uniqKey="Dong K">K. Dong</name></author><author><name sortKey="Lin, F" uniqKey="Lin F">F. Lin</name></author><author><name sortKey="Wang, X" uniqKey="Wang X">X. Wang</name></author><author><name sortKey="Li, B" uniqKey="Li B">B. Li</name></author><author><name sortKey="Shen, J J" uniqKey="Shen J">J.J. Shen</name></author><author><name sortKey="Zhang, Q" uniqKey="Zhang Q">Q. Zhang</name></author><author><name sortKey="Wang, R" uniqKey="Wang R">R. Wang</name></author><author><name sortKey="Zhang, H Z" uniqKey="Zhang H">H.Z. Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pan, R" uniqKey="Pan R">R. Pan</name></author><author><name sortKey="Ruvolo, V R" uniqKey="Ruvolo V">V.R. Ruvolo</name></author><author><name sortKey="Wei, J" uniqKey="Wei J">J. Wei</name></author><author><name sortKey="Konopleva, M" uniqKey="Konopleva M">M. Konopleva</name></author><author><name sortKey="Reed, J C" uniqKey="Reed J">J.C. Reed</name></author><author><name sortKey="Pellecchia, M" uniqKey="Pellecchia M">M. Pellecchia</name></author><author><name sortKey="Andreeff, M" uniqKey="Andreeff M">M. Andreeff</name></author><author><name sortKey="Ruvolo, P P" uniqKey="Ruvolo P">P.P. Ruvolo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Woo, S M" uniqKey="Woo S">S.M. Woo</name></author><author><name sortKey="Min, K J" uniqKey="Min K">K.J. Min</name></author><author><name sortKey="Seo, B R" uniqKey="Seo B">B.R. Seo</name></author><author><name sortKey="Seo, Y H" uniqKey="Seo Y">Y.H. Seo</name></author><author><name sortKey="Jeong, Y J" uniqKey="Jeong Y">Y.J. Jeong</name></author><author><name sortKey="Kwon, T K" uniqKey="Kwon T">T.K. Kwon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sun, X P" uniqKey="Sun X">X.P. Sun</name></author><author><name sortKey="Zhang, X" uniqKey="Zhang X">X. Zhang</name></author><author><name sortKey="He, C" uniqKey="He C">C. He</name></author><author><name sortKey="Qiao, H" uniqKey="Qiao H">H. Qiao</name></author><author><name sortKey="Jiang, X" uniqKey="Jiang X">X. Jiang</name></author><author><name sortKey="Jiang, H" uniqKey="Jiang H">H. Jiang</name></author><author><name sortKey="Sun, X" uniqKey="Sun X">X. Sun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Souers, A J" uniqKey="Souers A">A.J. Souers</name></author><author><name sortKey="Leverson, J D" uniqKey="Leverson J">J.D. Leverson</name></author><author><name sortKey="Boghaert, E R" uniqKey="Boghaert E">E.R. Boghaert</name></author><author><name sortKey="Ackler, S L" uniqKey="Ackler S">S.L. Ackler</name></author><author><name sortKey="Catron, N D" uniqKey="Catron N">N.D. Catron</name></author><author><name sortKey="Chen, J" uniqKey="Chen J">J. Chen</name></author><author><name sortKey="Dayton, B D" uniqKey="Dayton B">B.D. Dayton</name></author><author><name sortKey="Ding, H" uniqKey="Ding H">H. Ding</name></author><author><name sortKey="Enschede, S H" uniqKey="Enschede S">S.H. Enschede</name></author><author><name sortKey="Fairbrother, W J" uniqKey="Fairbrother W">W.J. Fairbrother</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Asghar, U" uniqKey="Asghar U">U. Asghar</name></author><author><name sortKey="Witkiewicz, A K" uniqKey="Witkiewicz A">A.K. Witkiewicz</name></author><author><name sortKey="Turner, N C" uniqKey="Turner N">N.C. Turner</name></author><author><name sortKey="Knudsen, E S" uniqKey="Knudsen E">E.S. Knudsen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, Q" uniqKey="Liu Q">Q. Liu</name></author><author><name sortKey="Hilsenbeck, S" uniqKey="Hilsenbeck S">S. Hilsenbeck</name></author><author><name sortKey="Gazitt, Y" uniqKey="Gazitt Y">Y. Gazitt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Longley, D B" uniqKey="Longley D">D.B. Longley</name></author><author><name sortKey="Harkin, D P" uniqKey="Harkin D">D.P. Harkin</name></author><author><name sortKey="Johnston, P G" uniqKey="Johnston P">P.G. Johnston</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Subbarayan, P R" uniqKey="Subbarayan P">P.R. Subbarayan</name></author><author><name sortKey="Lee, K" uniqKey="Lee K">K. Lee</name></author><author><name sortKey="Ardalan, B" uniqKey="Ardalan B">B. Ardalan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wilson, P M" uniqKey="Wilson P">P.M. Wilson</name></author><author><name sortKey="Danenberg, P V" uniqKey="Danenberg P">P.V. Danenberg</name></author><author><name sortKey="Johnston, P G" uniqKey="Johnston P">P.G. Johnston</name></author><author><name sortKey="Lenz, H J" uniqKey="Lenz H">H.J. Lenz</name></author><author><name sortKey="Ladner, R D" uniqKey="Ladner R">R.D. Ladner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gump, J M" uniqKey="Gump J">J.M. Gump</name></author><author><name sortKey="Thorburn, A" uniqKey="Thorburn A">A. Thorburn</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Taïwan</li></country></list><tree><noCountry><name sortKey="Hsin, I Lun" sort="Hsin, I Lun" uniqKey="Hsin I" first="I-Lun" last="Hsin">I-Lun Hsin</name><name sortKey="Hung, Wei Li" sort="Hung, Wei Li" uniqKey="Hung W" first="Wei-Li" last="Hung">Wei-Li Hung</name><name sortKey="Ko, Jiunn Liang" sort="Ko, Jiunn Liang" uniqKey="Ko J" first="Jiunn-Liang" last="Ko">Jiunn-Liang Ko</name></noCountry><country name="Taïwan"><noRegion><name sortKey="Chou, Ying Hsiang" sort="Chou, Ying Hsiang" uniqKey="Chou Y" first="Ying-Hsiang" last="Chou">Ying-Hsiang Chou</name></noRegion><name sortKey="Chou, Ying Hsiang" sort="Chou, Ying Hsiang" uniqKey="Chou Y" first="Ying-Hsiang" last="Chou">Ying-Hsiang Chou</name><name sortKey="Wang, Po Hui" sort="Wang, Po Hui" uniqKey="Wang P" first="Po-Hui" last="Wang">Po-Hui Wang</name><name sortKey="Wang, Po Hui" sort="Wang, Po Hui" uniqKey="Wang P" first="Po-Hui" last="Wang">Po-Hui Wang</name><name sortKey="Wang, Po Hui" sort="Wang, Po Hui" uniqKey="Wang P" first="Po-Hui" last="Wang">Po-Hui Wang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000368 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000368 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:7016694
|texte= The Application of Arsenic Trioxide in Ameliorating ABT-737 Target Therapy on Uterine Cervical Cancer Cells through Unique Pathways in Cell Death
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:31906234" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ChloroquineV1
| This area was generated with Dilib version V0.6.33. |  |